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Index > Protein center > Setd8(Gene name) > Mouse
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  • Setd8 (Gene name),
  • N-lysine methyltransferase SETD8 (Protein name ),  SETD8_MOUSE from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • Gene name:
    Setd8;
    Protein name:
    N-lysine methyltransferase SETD8;
    Alternative:
    2.1.1.43;Histone-lysine N-methyltransferase SETD8);H4-K20-HMTase SETD8;SET domain-containing protein 8;PR/SET domain-containing protein 07(PR-Set7;PR/SET07);
    Organism:
    Mouse (Mus musculus). 
    General Annotation
    Sub Unit:
    Interacts with L3MBTL1.
    Function:
    Protein-lysine N-methyltransferase that monomethylates both histones and non-histone proteins. Specifically monomethylates 'Lys-20' of histone H4 (H4K20me1). H4K20me1 is enriched during mitosis and represents a specific tag for epigenetic transcriptional repression. Mainly functions in euchromatin regions, thereby playing a central role in the silencing of euchromatic genes. Required for cell proliferation, probably by contributing to the maintenance of proper higher order structure of DNA during mitosis. Involved in chromosome condensation and proper cytokinesis. Nucleosomes are preferred as substrate compared to free histones. Mediates monomethylation of p53/TP53 at 'Lys-382', leading to repress p53/TP53-target genes.
    Subcellular Location:
    Nucleus Chromosome Specifically localizes to mitotic chromosomes. Associates with silent chromatin on euchromatic arms. Not associated with constitutive heterochromatin.
    Protein Attributes:
    Sequence length:
    349
    Sequence:
    50:
    MARGRKMCKP | RAVEAAAAAV | AATAPGPEMV | EQRGPGRPRS | DGENVFAGQS | 
    100:
    KIYAYMSPNK | CSAMRSPLQE | ENSVAHHEVK | CPGKPLAGIY | RKREEKRNTG | 
    150:
    NVIRSAVKSD | EQKSKDTRRG | PLAPFPNQKS | EAAEPPKTPP | PSCDSTNVAV | 
    200:
    AKQALKKSLK | GKQAPRKKSQ | GKTQQNRKLT | DFYPVRRSSR | KSKAELQSEE | 
    250:
    RKKNELIESG | KEEGMKIDLI | DGKGRGVIAT | KQFSRGDFVV | EYHGDLIEIT | 
    300:
    DAKKREALYV | QDPSTGCYMY | YFQYLSKTYC | VDATQETNRL | GRLINHSKCG | 
    349:
    NCQTKLHDID | GVPHLILIAS | RDIAAGEELL | YDYGDRSKAS | IEAYPWLKH
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    SMR:
    Pfam:
    String:
    UniGene:
    KEGG:
    Uniprot:
     
    FOR
    ELISA Kit for Mouse N-lysine methyltransferase SETD8
    Cat.:
    E3859b
    Price:
    Please sign in first.
    MSDS:
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    Packing:
    96T
    ELISA Kit for Mouse N-lysine methyltransferase SETD8
    Cat.:
    E3859m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    ELISA Kit for Mouse N-lysine methyltransferase SETD8
    Cat.:
    E3859h
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Mouse N-lysine methyltransferase SETD8
    Cat.:
    U3859m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Mouse N-lysine methyltransferase SETD8
    Cat.:
    U3859b
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Mouse N-lysine methyltransferase SETD8
    Cat.:
    U3859h
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Polyclonal Antibody for Mouse N-lysine methyltransferase SETD8
    Cat.:
    P3859Rb-h
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Mouse N-lysine methyltransferase SETD8
    Cat.:
    P3859Rb-m
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Mouse N-lysine methyltransferase SETD8
    Monoclonal Antibody for Mouse N-lysine methyltransferase SETD8
    Monoclonal Antibody for Mouse N-lysine methyltransferase SETD8
    Monoclonal Antibody for Mouse N-lysine methyltransferase SETD8
    Protein for Mouse N-lysine methyltransferase SETD8
    Protein for Mouse N-lysine methyltransferase SETD8
    Protein for Mouse N-lysine methyltransferase SETD8

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    Precision
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    Linearity
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    References
    1. 1.
      "The transcriptional landscape of the mammalian genome."
      Carninci P. , Kasukawa T. , Katayama S. , Gough J. , Frith M.C. , Maeda N. , Oyama R. , Ravasi T. , Lenhard B. , Wells C. , Kodzius R. , Shimokawa K. , Bajic V.B. , Brenner S.E. , Batalov S. , Forrest A.R. , Zavolan M. , Davis M.J. , more...
      Science309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
      strain: C57BL/6J.
      tissue: Thymus.
    2. 2.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
      strain: NMRI.
      tissue: Mammary tumor.
    3. 3.
      "The tumor suppressor SirT2 regulates cell cycle progression and genome stability by modulating the mitotic deposition of H4K20 methylation."
      Serrano L. , Martinez-Redondo P. , Marazuela-Duque A. , Vazquez B.N. , Dooley S.J. , Voigt P. , Beck D.B. , Kane-Goldsmith N. , Tong Q. , Rabanal R.M. , Fondevila D. , Munoz P. , Kruger M. , Tischfield J.A. , Vaquero A.
      Genes Dev.27:639-653(2013) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SUBCELLULAR LOCATION
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